Large ribosomal subunit protein uL30m (MRPL30)

Large ribosomal subunit protein uL30m (MRPL30) is a protein encoded by the nuclear genome and imported into mitochondria, where it forms part of the 39S large subunit of the mitochondrial ribosome (mitoribosome)[1][3][6]. It is essential for mitochondrial protein synthesis, facilitating the translation of mitochondrial genome-encoded proteins, which are crucial for cellular energy production via oxidative phosphorylation[1][3][5]. MRPL30 does not have a recognized direct role as a therapeutic target, nor are there known drugs directly interacting with it. However, perturbations in mitochondrial ribosomal proteins as a group, including MRPL30, may be implicated in mitochondrial diseases and, in some contexts, cancer biology[5]. The mitochondrial ribosomal proteins are distinct from their cytoplasmic counterparts in structure and sequence, and their deficiency may disrupt mitochondrial function[1][3][9].

Other names

39S ribosomal protein L30, mitochondrial39S ribosomal protein L28, mitochondrialL30mtL28mtMRP-L30MRP-L28MRPL28MRPL28MRPML28HSPC249uL30mlarge ribosomal subunit protein uL30m