Late cornified envelope protein 1A (LCE1A)

Late cornified envelope protein 1A is a structural protein encoded by the LCE1A gene, located in the late cornified envelope (LCE) gene cluster within the epidermal differentiation complex on chromosome 1[2][7]. The protein serves as a precursor for the cornified envelope of the stratum corneum, the outermost layer of the skin, and is expressed relatively late during skin development[5][6]. LCE1A is regulated by the tumor suppressor p53 and appears to play a role in modulating histone methylation by interacting with protein arginine methyltransferase 5 (PRMT5)[1]. Although not a classical drug target, its connection to epidermal differentiation, stress response (UV, DNA damage), and possible tumor suppressor functions makes it relevant for research in dermatology and cancer biology[1][2][3][6].

Other names

Late cornified envelope protein 1ALCE1ALEP1Late envelope protein 1

Not applicable; no approved or investigational drugs with mechanisms directly acting on LCE1A