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Target intelligence / Profile preview
Late cornified envelope protein 2A (LCE2A)
- Target
- LCE2A
- Molecular classification
- Other (Cornified envelope protein family)
01
Overview
Late cornified envelope protein 2A (LCE2A) is a precursor protein involved in the formation of the cornified envelope, a structure essential for maintaining the barrier function of the skin’s outermost layer, the stratum corneum. LCE2A incorporates into the cornified envelope late during the process of epidermal differentiation and cornification. It belongs to a cluster of proteins important for keratinization and skin barrier integrity. There is no evidence that LCE2A is itself a major therapeutic target, receptor, enzyme, or transporter.
- Other names
- Late envelope protein 9LEP9late cornified envelope 2Alate cornified envelope protein 2ALCE2A
02
Biological functions
Formation of cornified envelopeEpidermal differentiationKeratinizationSkin barrier function
03
Disease associations
Other (no direct association with major diseases as a therapeutic target, but alterations in related LCE proteins may be linked to skin disorders)
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