Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Late cornified envelope protein 6A (LCE6A)
- Target
- LCE6A
- Molecular classification
- Structural protein, Member of the late cornified envelope (LCE) family, Epidermal differentiation complex protein, Other (not a receptor, enzyme, transporter, etc.)
01
Overview
Late cornified envelope protein 6A (LCE6A) is a member of the LCE protein family localized within the epidermal differentiation complex on human chromosome 1q21. LCE6A is involved in the late stages of cornified envelope formation in differentiated keratinocytes, contributing to the mechanical integrity and barrier function of the skin’s outer layer. Its expression is induced in response to calcium signaling and ultraviolet irradiation during terminal differentiation. LCE family members—including LCE6A—are incorporated into the cornified envelope by transglutaminase-mediated cross-linking, and participate in the modulation of the epidermal barrier’s quality and resistance to environmental insult. There are currently no documented disease mutations, drug interactions, nor established use as a biomarker or therapeutic target for LCE6A in clinical practice.
- Other names
- LCE6AC1orf44late cornified envelope protein 6A
02
Mechanism of action
None documented for drugs (as LCE6A is not a known therapeutic target)
03
Biological functions
Epidermal barrier formationStructural constituent of cornified envelope in keratinocytesInvolved in barrier maturation during terminal differentiation of keratinocytes
04
Disease associations
Other (no direct association with cancer, inflammation, or other major disease roles reported; potential relevance in barrier disorders or skin differentiation is yet to be fully elucidated)
05
Safety considerations
None reported; therapeutic targeting not described
Beyond the preview
Go deeper on Late cornified envelope protein 6A (LCE6A).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Late cornified envelope protein 6A (LCE6A).