Late cornified envelope protein 7A (LCE7A)

Late cornified envelope protein 7A (LCE7A) is a member of the late envelope protein (LEP) family, a cluster of genes in the human epidermal differentiation complex at chromosome 1q21[1][3]. LCE proteins are structural components of the *cornified envelope*, a tough, insoluble layer formed late during epidermal differentiation in keratinocytes, providing an essential part of the skin's protective barrier[1][3]. LCE7A and related LEP family members are incorporated into the envelope at late stages of barrier maturation, after proteins such as loricrin and small proline-rich region proteins, and are substrates for epidermal transglutaminases that catalyze their cross-linking[1][3]. The principal biological role of LCE7A is believed to be the modulation and maintenance of barrier function in skin and other barrier epithelia through structural integration into the cornified envelope[3]. There is currently no evidence that LCE7A is a pharmacological or therapeutic target (such as a receptor, enzyme, transporter, or classical signaling protein), nor are there any known drugs, mechanisms, or biomarker applications related to this protein. Scientific knowledge does not indicate a direct involvement in major disease states, although variants in related LCE proteins may influence skin barrier properties and susceptibility to conditions such as psoriasis; direct clinical or functional data for LCE7A itself are lacking. **Justification for "is_incorrect: true":** - LCE7A is not a therapeutic target, receptor, enzyme, or other druggable protein class. It is a structural protein incorporated into the cornified envelope during terminal keratinocyte differentiation[1][3]. - There is no evidence LCE7A is being targeted by drugs, is used as a biomarker, or is the subject of disease-modifying interventions. - No credible pharmacological or receptor function is assigned to LCE7A. It does not fit standard definitions for a target in drug discovery or therapeutics. **Summary:** LCE7A is a late cornified envelope protein of structural significance in skin differentiation and barrier function, not a druggable target, receptor, or enzyme. No drugs, disease associations, or targeting mechanisms are known for this protein[1][3][4].

Other names

Late cornified envelope 7Alate cornified envelope 7A proteinLCE7A