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Persistent Sodium Current (INaP)
- Target
- INaP
- Molecular classification
- Ion Channel, Voltage-Gated Ion Channel, Sodium Channel
01
Overview
The persistent sodium current (INaP) is a sub-threshold inward electrical current generated by voltage-gated sodium channels (NaVs) that do not fully inactivate after membrane depolarization. It plays a role in regulating neuronal excitability, pacemaking, and sensory signal prolongation, and is implicated in diseases like epilepsy, neuropathic pain, cardiac arrhythmia, and ALS.
- Other names
- Late Sodium CurrentNon-inactivating Sodium CurrentSlow-inactivating Sodium Current
02
Mechanism of action
Blockage of persistent sodium current
03
Biological functions
Neuronal excitability modulationPacemaking activitySensory signal prolongationMembrane potential regulation
04
Disease associations
EpilepsyNeuropathic painCardiac arrhythmiaAmyotrophic lateral sclerosis (ALS)
05
Safety considerations
Potential for pro-arrhythmic effects with some blockersOff-target effects due to non-selective drug bindingVariability in drug efficacy across different sodium channel isoforms
06
Interacting drugs
GS967
21 more in the full profile.
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