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Target intelligence / Profile preview
Latent transforming growth factor beta binding protein 1 (LTBP1)
- Target
- LTBP1
- Molecular classification
- Other (Extracellular matrix protein), TGF-beta binding protein
01
Overview
Latent transforming growth factor beta binding protein 1 (LTBP1) is an extracellular matrix glycoprotein essential for the proper folding, secretion, localization, and activation of TGF-beta isoforms (TGFB1, TGFB2, TGFB3)[6][3][1]. LTBP1 binds covalently to the latent form of TGF-beta and directs its association with the extracellular matrix, where it regulates the growth factor's availability and activation by integrin-mediated mechanical signals and matrix remodeling enzymes[1][3][6]. LTBP1 is not a classical therapeutic target (like a receptor or enzyme) but is implicated in pathological processes such as tissue fibrosis and cancer due to its role in TGF-beta signaling regulation[1][5][6]. Various alternatively spliced isoforms of LTBP1 exist, reflecting a complex regulation and functional diversity[3][5].
- Other names
- Latent-transforming growth factor beta-binding protein 1LTBP-1
02
Biological functions
Extracellular matrix localizationStorage and activation of TGF-betaRegulation of TGF-beta signaling
03
Disease associations
CancerFibrosisCardiovascular diseaseOther
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