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Target intelligence / Profile preview
Latrophilin Receptor LAT-1/LAT-2 (LPHN1/LAT-1 & LPHN2/LAT-2)
- Target
- LPHN1/LAT-1 & LPHN2/LAT-2
- Molecular classification
- Adhesion G-protein-coupled receptor (aGPCR), GPCR, Receptor
01
Overview
Latrophilins (LAT-1 and LAT-2) are adhesion G-protein-coupled receptors (GPCRs) crucial for cell signaling, synapse formation, and tissue polarity. LAT-1 is primarily brain-specific and involved in synapse maturation and exocytosis. LAT-2 is ubiquitously expressed and implicated in breast cancer biology and postsynaptic target recognition. Both interact with ligands like alpha-latrotoxin and teneurins, activating G-protein pathways and influencing calcium release. In C. elegans, LAT-1 is vital for establishing anterior-posterior tissue polarity.
- Other names
- Latrophilin 1LPHN1ADGRL1CIRLLatrophilin 2LPHN2ADGRL2
02
Mechanism of action
Ligand binding induces receptor reassociation, activating intracellular G-protein–mediated pathways and releasing Ca²⁺ from internal stores, leading to neurotransmitter or hormone secretion/exocytosis.
03
Biological functions
Cell adhesionSignal transductionSynapse formationSynapse maturationExocytosisTissue polarityNeurotransmitter release
04
Disease associations
Neurodevelopmental disordersBreast cancer
05
Safety considerations
Potential for off-target effects due to widespread expression (LAT-2)Implications for neural connectivity and signal transmission
06
Interacting drugs
alpha-Latrotoxin
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