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Target intelligence / Profile preview
LCK proto-oncogene, Src family tyrosine kinase (LCK)
- Target
- LCK
- Molecular classification
- Enzyme, Protein Tyrosine Kinase, Src Family Kinase
01
Overview
LCK is a member of the Src family of protein tyrosine kinases and plays a critical role in T-cell development and activation. It initiates the T-cell receptor (TCR) signaling cascade by phosphorylating ITAMs within CD3 subunits and TCR-gamma chains. Dysregulation can result in immunodeficiency or contribute to oncogenic transformation. Lck is an established drug target for immunomodulation.
- Other names
- p56lckLskYT16
02
Mechanism of action
Inhibition of Lck kinase activity
03
Biological functions
T-cell receptor signalingT-cell developmentT-cell activationImmunoreceptor tyrosine-based activation motif (ITAM) phosphorylationSignal transduction
04
Disease associations
Immunodeficiency disordersSevere Combined Immunodeficiency (SCID)Immunodeficiency 22CancerTriple-negative breast cancer
05
Safety considerations
ImmunosuppressionPotential for off-target effects due to kinase family similarity
06
Interacting drugs
Lck inhibitors
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