LDLRAD4 antisense RNA 1 (LDLRAD4-AS1)

LDLRAD4 antisense RNA 1 (LDLRAD4-AS1) is a long noncoding RNA (lncRNA) transcribed antisense to the LDLRAD4 gene. It is primarily nuclear in colorectal cancer cells, where it is upregulated and associated with poor prognosis. LDLRAD4-AS1 promotes colorectal cancer progression and metastasis by downregulating the mRNA stability of the LDLRAD4 gene, which acts as a suppressor of cell migration and epithelial-mesenchymal transition (EMT). By promoting EMT through upregulation of the transcription factor Snail and decreasing E-cadherin, LDLRAD4-AS1 enhances the invasive and migratory properties of cancer cells. It has been suggested as both a potential biomarker and a therapeutic target in colorectal cancer[1][2]. Key Notes: - The query referred to "LDLRAD4 antisense RNA 3 (LDLRAD4-AS3)", but scientific literature only validates "LDLRAD4 antisense RNA 1 (LDLRAD4-AS1)" as a functionally characterized lncRNA at the LDLRAD4 locus[1][2]. - No reputable sources or databases provide functional or disease-association data for "LDLRAD4-AS3", suggesting either a misspelling or else the target is not yet established in biomedical literature. - Descriptions, aliases, and roles above refer to LDLRAD4-AS1, the actual known molecule; LDLRAD4-AS3 cannot be accurately annotated given current evidence. - If user intent was to refer to a different antisense RNA at the LDLRAD4 locus, clarification is needed, but there is no basis for LDLRAD4-AS3 in major sources as of 2025[1][2]. Summary: No information is available for "LDLRAD4 antisense RNA 3 (LDLRAD4-AS3)" as a functionally characterized target. "LDLRAD4-AS1" is the canonical, disease-relevant lncRNA antisense to LDLRAD4, and this entry is for LDLRAD4-AS1 due to the apparent error in the query[1][2].

Other names

LDLRAD4-AS1LDLRAD4 antisense RNA 1Long noncoding RNA LDLRAD4-AS1

Not targeted by approved drugs; if targeted, downregulation would inhibit function as an oncogenic lncRNA