Lebercilin-like protein (LCA5L)

Lebercilin-like protein (LCA5L), encoded by the *LCA5L* (C21orf13) gene, is a human protein thought to be associated with ciliary or centrosomal functions, similar to but distinct from lebercilin (LCA5)[5]. It shares sequence similarity with the well-characterized lebercilin, a ciliary protein involved in photoreceptor cell function and mutated in Leber congenital amaurosis[2][5]. However, as of now, LCA5L itself is not characterized as a disease-associated gene or a classical therapeutic target such as a receptor or enzyme. There are no known drugs targeting LCA5L, nor evidence of its role as a biomarker or target in human disease. Much of the literature and research focus is on LCA5, not LCA5L, and the two should not be conflated. If the intent is to refer to "lebercilin" (*LCA5*), a well-established target in inherited blindness, then LCA5L is an incorrect or ambiguous designation for a therapeutic target. Note: Based on the provided aliases and existing literature, LCA5L refers to a *lebercilin-like* protein distinct from the canonical lebercilin (LCA5), which is the protein associated with Leber congenital amaurosis type 5[5][2]. There is insufficient evidence to consider LCA5L a therapeutic target. The canonical disease-associated gene/protein is lebercilin (LCA5), not lebercilin-like (LCA5L).

Other names

Lebercilin-like proteinLCA5LC21orf13MGC33295Leber congenital amaurosis 5-like proteinlebercilin likeleber congenital amaurosis 5-like protein