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Lecithin-cholesterol acyltransferase (LCAT)

Target: LCAT
Molecular classification: Enzyme

Overview

Lecithin-cholesterol acyltransferase (LCAT) is a key enzyme in lipid metabolism that catalyzes the conversion of free cholesterol into cholesteryl ester, a more hydrophobic form that can be efficiently transported within lipoproteins. It plays a central role in reverse cholesterol transport, removing excess cellular cholesterol from peripheral tissues and delivering it to the liver for excretion or redistribution. Deficiency or mutations in LCAT cause rare autosomal recessive disorders such as Familial LCAT deficiency and Fish-eye disease.

Other names: Phosphatidylcholine-sterol O-acyltransferase

Mechanism of action

N/A

Biological functions

Reverse cholesterol transportCholesterol esterification

Disease associations

Familial LCAT deficiencyFish-eye diseaseCardiovascular diseaseKidney disease

Safety considerations

Potential for off-target effectsDevelopment of neutralizing antibodies

Biomarkers

LCAT activity levels

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