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Target intelligence / Profile preview
Lectin-like oxidized LDL receptor-1 (LOX-1)
- Target
- LOX-1
- Molecular classification
- Receptor, Scavenger receptor, C-type lectin-like receptor
01
Overview
Lectin-like oxidized LDL receptor-1 (LOX-1) is a type II integral membrane glycoprotein that plays a crucial role in the pathogenesis of atherosclerosis by binding and internalizing oxidized LDL (oxLDL). It is involved in endothelial dysfunction, inflammation, and is expressed in endothelial cells, macrophages, platelets, and smooth muscle cells. LOX-1's expression is induced by various proatherogenic stimuli and inflammatory cytokines, and it may also interact with pathogens and be involved in cell adhesion processes[1][2][6][10].
- Other names
- Oxidized LDL receptor 1OLR1CLEC8ASCARE1
02
Mechanism of action
Inhibitors like BI-0115 work by blocking the uptake of oxidized LDL, potentially reducing inflammation and endothelial dysfunction.
03
Biological functions
Signal transductionImmune responseEndothelial dysfunctionCell adhesionApoptosis regulation
04
Disease associations
Cardiovascular diseaseAtherosclerosisInflammationCancer
05
Safety considerations
Targeting LOX-1 may have implications for endothelial function and inflammation management.
06
Interacting drugs
BI-0115
1 more in the full profile.
07
Biomarkers
Soluble LOX-1 has been studied as a potential biomarker for cardiovascular risk.
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