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Target intelligence / Profile preview
Lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1)
- Target
- LOX-1
- Molecular classification
- C-type lectin superfamily, Type II transmembrane glycoprotein, Receptor
01
Overview
Lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) is a type II transmembrane glycoprotein and a member of the C-type lectin superfamily. It functions as a receptor for oxidized low-density lipoproteins (oxLDL) and plays a crucial role in the development of atherosclerosis and other cardiovascular diseases. LOX-1 is expressed in various cell types, including vascular endothelial cells, monocytes/macrophages, and smooth muscle cells. Beyond cardiovascular disease, LOX-1 is involved in immune responses and potentially cancer immunotherapy.
- Other names
- OLR-1oxidized LDL receptor 1
02
Mechanism of action
Downregulation of LOX-1 expression/activity
03
Biological functions
Mediating uptake of oxLDLEndothelial dysfunctionMonocyte adhesionSmooth muscle proliferationSmooth muscle migrationSmooth muscle apoptosisPlatelet activationImmune responseAntigen cross-presentationBinding of bacterial components
04
Disease associations
AtherosclerosisCardiovascular diseaseHypercholesterolemiaCancer
05
Interacting drugs
Statins
3 more in the full profile.
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