Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Lectin-like transcript 1 (LLT1)
- Target
- LLT1
- Molecular classification
- C-type lectin-like receptors, Receptor
01
Overview
Lectin-like transcript 1 (LLT1) is a C-type lectin-like receptor that acts as a ligand for NKRP1A/CD161, an inhibitory receptor primarily found on NK cells and T lymphocytes. LLT1 is upregulated on activated immune cells during inflammation and infection. Its interaction with NKRP1A inhibits NK cell cytotoxicity but can costimulate T cell proliferation and cytokine production. LLT1 plays a role in tumor immune evasion, making it a potential target for cancer immunotherapy.
- Other names
- CLEC2DOCILCLAX
02
Mechanism of action
Inhibition of NKRP1A/CD161 interaction to enhance NK cell activity; modulation of T cell response
03
Biological functions
Immune regulationInhibition of NK cell cytotoxicityT cell costimulationModulation of immune response
04
Disease associations
CancerInflammationInfection
05
Safety considerations
Potential for immune-related adverse events due to broad immune modulation
06
Biomarkers
LLT1 expression in tumorsDensity of LLT1-expressing tumor-infiltrating lymphocytes
Beyond the preview
Go deeper on Lectin-like transcript 1 (LLT1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Lectin-like transcript 1 (LLT1).