Target intelligence / Profile preview

Lectin mannose-binding 2-like protein (LMAN2L)

Target: LMAN2L
Molecular classification: L-type lectin, Cargo receptor, Type 1 membrane protein, Endoplasmic reticulum/Golgi apparatus protein

Overview

Lectin mannose-binding 2-like protein (LMAN2L) is a member of the L-type lectin family of type 1 membrane proteins and is primarily localized in the endoplasmic reticulum (ER) of mammalian cells. Unlike other L-type lectins that cycle between the ER and Golgi, LMAN2L is a non-cycling resident protein of the ER, functioning as a cargo receptor for glycoproteins destined for secretion or membrane localization. It helps regulate the export of properly folded glycoproteins to the Golgi apparatus and facilitates sorting of misfolded glycoproteins for degradation via the ubiquitin-proteasome pathway. Its gene is associated with certain intellectual developmental disorders but is not known to be a direct target of approved pharmacological agents or major therapeutic programs.

Other names: VIP36-like proteinVIPLMRT52LMAN2-like proteinPSEC0028UNQ368/PRO704DKFZp564L2423MRD69

Biological functions

Cargo receptor for glycoproteins in the early secretory pathwayRegulation of export of folded glycoproteins from endoplasmic reticulum to the GolgiPossibly regulates the exchange of misfolded glycoproteins for degradation via the ubiquitin-proteasome pathway

Disease associations

Intellectual developmental disorder, autosomal recessive 52Intellectual developmental disorder, autosomal dominant 69

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