Left-to-right inter-atrial blood flow

"Left-to-right inter-atrial blood flow" refers to an **abnormal pattern of blood movement across the atria**, typically through a defect such as an atrial septal defect (ASD), where oxygenated blood from the left atrium flows into the right atrium. This is not a molecule or receptor but rather a **physiological phenomenon or hemodynamic consequence of structural cardiac defects**, most commonly congenital in origin. The main causes include ASD, ventricular septal defect (VSD), patent ductus arteriosus (PDA), and other septal abnormalities that allow communication between systemic and pulmonary circulations[1][6]. In these conditions: - The increased compliance of the right ventricle compared to the left favors this abnormal flow direction in most patients with ASD. - Chronic excessive pulmonary blood flow can lead to vascular remodeling, irreversible pulmonary hypertension, right heart enlargement/failure, and eventually reversal of shunt direction if untreated (Eisenmenger syndrome)[2][4]. Therapeutically, recent innovations include percutaneously implanted devices like the V-Wave device that intentionally create controlled unidirectional interatrial shunts in select patients with refractory heart failure to decompress elevated left atrial pressures—this is not drug-based therapy but rather mechanical intervention[3]. Because "left-to-right inter-atrial blood flow" describes a pathophysiological process—not a discrete molecular target—it is **not considered a therapeutic target like receptors or enzymes**, nor does it have canonical molecular identifiers. It should be classified under "Other" for molecular classification. If you require structured data on actual molecules/receptors involved in regulating cardiac development or function related to these processes—such as ion channels or signaling proteins—please specify further.

Other names

Left-to-right shuntInteratrial left-to-right shuntCardiac left-to-right shunt

Not applicable for drugs; for devices, mechanical decompression of the left atrium via creation of a unidirectional interatrial shunt[3]