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Target intelligence / Profile preview
Left ventricular assist device (LVAD)
- Target
- LVAD
01
Overview
A left ventricular assist device (LVAD) is an implantable mechanical pump used as a circulatory support for patients with advanced heart failure whose left ventricle cannot adequately pump blood. The LVAD pulls blood from the left ventricle and pumps it into the aorta, ensuring sufficient systemic perfusion. LVADs can serve as a bridge to heart transplantation, as destination therapy, or as a bridge to recovery in selected patients. Major risks include bleeding, infection, device malfunction, and other complications related to both the device and underlying cardiac disease
- Other names
- Left ventricular circulatory supportMechanical circulatory support (when referring to LVAD specifically)LVAD
02
Mechanism of action
Mechanical support—LVADs are surgically implanted pumps that assist the left ventricle in delivering blood to the aorta and systemic circulation
03
Disease associations
Cardiovascular diseasespecifically in end-stage or advanced heart failure
04
Safety considerations
Bleedinginfectionright heart failuredevice malfunctionthromboembolismstrokehemolysisrenal dysfunctionhepatic dysfunctionpsychiatric episodes
05
Interacting drugs
Anticoagulants (e.g., warfarin, heparin; used to prevent clotting with the device in place)
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