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Target intelligence / Profile preview
Leishmania intracellular amastigote
- Molecular classification
- Other (Whole organism/Pathogen stage)
01
Overview
Leishmania intracellular amastigotes are the non-motile, spherical life cycle stage of the Leishmania protozoan parasite that resides within the phagolysosomes of mammalian host macrophages (World Health Organization, 2023). This stage is responsible for the clinical manifestations}
- Other names
- Leishmania amastigoteIntracellular amastigote stageTissue-stage Leishmania
02
Mechanism of action
Drugs targeting this stage act through various mechanisms including disruption of the parasite cell membrane (Amphotericin B), inhibition of protein synthesis (Paromomycin), interference with thiol metabolism and DNA topoisomerase (Antimonials), and induction of apoptosis-like cell death (Miltefosine).
03
Biological functions
Parasitic replicationImmune evasionHost cell modulationIntracellular survival
04
Disease associations
InfectionVisceral leishmaniasisCutaneous leishmaniasisMucocutaneous leishmaniasis
05
Safety considerations
NephrotoxicityCardiotoxicityTeratogenicity (Miltefosine)Emerging drug resistanceInjection site reactions
06
Interacting drugs
Miltefosine
5 more in the full profile.
07
Biomarkers
Parasite load (qPCR)rK39 antigenLeishmanin skin test
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