Leishmanolysin-like pseudogene

The leishmanolysin-like pseudogene (ENSG00000224245, LOC100421692) is a human genome locus predicted to have sequence similarity to leishmanolysin proteins of the metallopeptidase M8 family, but it does not encode a functional protein due to disabling mutations and is classified as a pseudogene[4][5][6]. Human pseudogenes, including this locus, typically result from ancestral duplication or retrotransposition events, followed by degradation via frameshifts or premature stop codons that abolish protein-coding capacity[1][2][6]. Pseudogenes such as this may retain some sequence similarity to coding genes but are generally considered nonfunctional, not acting as receptors, enzymes, or drug targets. There is no evidence for involvement in any regulatory role, disease association, or pharmacological activity, nor is it a biomarker for clinical use[4][5][6].

Other names

LOC100421692LMLN pseudogeneLeishmanolysin-like (Metallopeptidase M8 Family) pseudogene