LEM domain-containing protein 2 (LEMD2)

LEM domain-containing protein 2 (LEMD2) is an integral inner nuclear membrane protein defined by a conserved LEM (LAP2-Emerin-MAN1) domain and two transmembrane segments[2][3]. It is ubiquitously expressed and interacts with nuclear lamins and barrier-to-autointegration factor (BAF), acting as a tether between chromatin and the nuclear envelope[2][3][1]. LEMD2 participates in chromatin organization, nuclear envelope reformation after mitosis, and genome stability, notably by anchoring transcriptionally inactive heterochromatin at the nuclear periphery[2][3][1]. Mutations in LEMD2 cause inherited diseases such as severe cardiomyopathy, cardiac fibrosis, arrhythmias, and cataracts, typically via loss of nuclear envelope integrity, chromatin mislocalization, DNA damage, p53 pathway activation, and apoptosis[2]. LEMD2 is one of several LEM domain family proteins, along with emerin and MAN1, which form critical hubs for integrating mechanical and signaling cues essential for tissue homeostasis[3][1]. Currently, LEMD2 itself is not a direct therapeutic target, and no drugs are known to act specifically on it[2].

Other names

LEMD2hLEM2dJ482C21.1NET25LEM2lamina-associated polypeptide-emerin-MAN1 domain containing 2CTRCT42MARUPS