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LEMD1 antisense RNA 1 (LEMD1-AS1)
- Target
- LEMD1-AS1
- Molecular classification
- Long noncoding RNA (lncRNA), Antisense RNA
01
Overview
LEMD1 antisense RNA 1 (LEMD1-AS1) is a long noncoding RNA (lncRNA) transcribed from the antisense strand of the LEMD1 gene. LEMD1-AS1 is implicated in several cancers, notably oral squamous cell carcinoma (OSCC) and ovarian cancer. In OSCC, LEMD1-AS1 is upregulated in metastatic tumors and promotes tumor cell migration and invasion by stabilizing LEMD1 mRNA, leading to increased LEMD1 protein levels and activation of the PI3K-AKT signaling pathway. In ovarian cancer, LEMD1-AS1 expression is reduced, and overexpression suppresses tumor cell proliferation, migration, and invasion through negative regulation of miR-183-5p and upregulation of TP53. LEMD1-AS1 is considered a potential therapeutic target and diagnostic/prognostic biomarker for cancer metastasis, though no direct drug interactions are currently reported[1][3][4][6][9].
- Other names
- LEMD1 antisense RNA 1 (non-protein coding)LEMD1-AS1
02
Mechanism of action
Modulates the stability and expression of its sense gene, LEMD1, through RNA duplex formation[1][3]. Acts as an RNA sponge for miR-183-5p, affecting TP53 expression in ovarian cancer[6][9].
03
Biological functions
Regulation of mRNA stabilityCell migrationCell invasionRegulation of cell proliferationModulation of apoptosisRegulation of signaling pathways (e.g., PI3K-AKT signaling)
04
Disease associations
Cancer (Oral squamous cell carcinoma, Ovarian cancer)Biomarker for metastasisTumor suppressor (in ovarian cancer)Oncogenic role (in oral squamous cell carcinoma)
05
Biomarkers
Predictor of metastasis in oral squamous cell carcinoma[1][2][3]Prognostic marker in ovarian cancer[4][6][9]
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