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Target intelligence / Profile preview
LEMD1 divergent transcript (LEMD1-DT)
- Target
- LEMD1-DT
- Molecular classification
- Other, Long non-coding RNA, antisense RNA
01
Overview
LEMD1 divergent transcript (LEMD1-DT or lncRNA LEMD1-AS1) is a long non-coding RNA transcribed from a region near the LEM domain containing 1 (LEMD1) gene. It has been shown to regulate the stability and expression of the LEMD1 gene, contributing to increased LEMD1 mRNA and protein levels. Through this regulatory effect, LEMD1-DT promotes cancer cell migration, invasion, and metastasis, at least in oral squamous cell carcinoma and potentially other cancers where LEMD1 functions as an oncogene. LEMD1-DT itself is not a protein-coding gene or classical therapeutic target, but its modulation of oncogenic pathways suggests potential as a biomarker or future target for cancer intervention.
- Other names
- LEMD1-DTLEMD1 divergent transcriptlncRNA LEMD1-AS1
02
Biological functions
Regulation of gene expressionRegulation of mRNA/protein stability (specifically stabilizes LEMD1 mRNA and modulates LEMD1 protein expression)
03
Disease associations
Cancer
04
Biomarkers
LEMD1-DT/LEMD1-AS1 is a potential biomarker for predicting cancer metastasis (in oral squamous cell carcinoma, as per current evidence)
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