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Target intelligence / Profile preview
Lemur Tyrosine Kinase 3 (LMTK3)
- Target
- LMTK3
- Molecular classification
- Serine/threonine kinase, Enzyme
01
Overview
Lemur tyrosine kinase 3 (LMTK3) is a protein kinase primarily functioning as a serine/threonine kinase. It is involved in gene regulation, protein trafficking, and oncogenesis. Overexpression is linked to several cancers, including breast, glioblastoma, and lung cancers. It also plays a role in central nervous system function, with knockout mice showing hyperactivity and cognitive impairments. The small molecule inhibitor C28 demonstrates anti-cancer activity by disrupting LMTK3's interaction with HSP90.
- Other names
- LMR3PPP1R101TYKLM3
02
Mechanism of action
Disrupts interaction with HSP90, leading to degradation of LMTK3; inhibits tumor growth and induces apoptosis; inhibits PKC; Direct phosphorylation of ERα
03
Biological functions
Gene regulationProtein traffickingOncogenesisRegulation of estrogen receptor alpha expressionGluA1 trafficking
04
Disease associations
CancerBreast cancerGlioblastomaNon-small cell lung cancerThyroid malignanciesBladder cancerColorectal cancer chemoresistanceSchizophreniaBipolar disorder
05
Interacting drugs
C28
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