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Lens epithelial cell protein LEP503 (LENEP)
- Target
- LENEP
- Molecular classification
- Other (small, leucine-rich protein specific to lens epithelial cells; not part of major protein families such as receptors, channels, enzymes, etc.)
01
Overview
Lens epithelial cell protein LEP503 (LENEP) is a highly conserved, small protein (61 amino acids, ~6.9 kDa) with a leucine-rich domain, localized to the lens epithelial cells on the anterior surface of the vertebrate lens[2][5][4]. Its expression is developmentally regulated, increasing postnatally in rat lens epithelium, and is thought to participate in lens epithelial cell differentiation and possibly lens development, but it does not appear to be a therapeutic target, receptor, or widely studied in disease pathology.
- Other names
- Lens epithelial proteinLens epithelial cell protein LEP503LENEPLEP503
02
Biological functions
Lens developmentLens epithelium differentiationPossibly DNA binding
03
Disease associations
Other (no established disease involvement; indirect role as lens epithelial cell biology may relate to cataractogenesis but LENEP itself is not implicated as a disease gene)
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