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Target intelligence / Profile preview
Lens Epithelium-Derived Growth Factor (LEDGF)
- Target
- LEDGF
- Molecular classification
- Transcription factor, Chromatin-binding protein, Transcriptional coactivator
01
Overview
Lens epithelium-derived growth factor (LEDGF), also known as PSIP1 or LEDGF/p75, is a chromatin-binding protein and transcriptional coactivator. It plays critical roles in cellular survival, gene regulation, and disease processes such as HIV infection and leukemia. Targeting the interaction between LEDGF/p75’s IBD and HIV integrase has been explored therapeutically because disrupting this interface inhibits viral replication. Aberrant expression or function of LEDGF can contribute to oncogenesis—notably mixed-lineage leukemia.
- Other names
- PSIP1LEDGF/p75
02
Mechanism of action
Inhibition of LEDGF/HIV integrase interaction to disrupt viral integration
03
Biological functions
Chromatin tetheringTranscriptional coactivationCell survivalGene regulation
04
Disease associations
HIV/AIDSLeukemiaCancer
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