Lens fiber major intrinsic protein (AQP0)

Lens fiber major intrinsic protein (AQP0) is the principal membrane protein in lens fiber cells, essential for maintaining lens transparency and homeostasis. As a member of the aquaporin family, it functions primarily as a water channel, enabling controlled water flux through lens fiber cell membranes. Unlike other aquaporins, its water permeability is lower and tightly regulated by post-translational modifications and interactions with proteins like calmodulin. Besides water transport, AQP0 acts as an adhesive molecule, forming cell–cell junctions crucial for lens spatial organization and stability. Disruption of AQP0’s function—by genetic mutation or abnormal post-translational changes—leads to impaired lens fiber cell communication and morphology, resulting in congenital cataract and other lens defects. AQP0 is not considered a therapeutic target, as there are currently no drugs in clinical use targeting this protein[1][2][3][4][5].

Other names

Aquaporin-0MIPMIP26MP26LIM1CTRCT15Aquaporin-CHIPmajor intrinsic protein of lens fiberlens fiber major intrinsic protein

Not applicable; there are no approved drugs acting directly via AQP0. Basic mechanisms if targeted would include modulation of water transport or interference with cell–cell adhesion[1][2]