Let-7d microRNA (let-7d)

Let-7d microRNA (let-7d) is a small, evolutionarily conserved non-coding RNA molecule that regulates gene expression at the post-transcriptional level. It is a member of the let-7 family, transcribed from a cluster on chromosome 9 and is abundant in human cells. Let-7d, like other let-7 family members, downregulates expression of key genes involved in cell proliferation, differentiation, apoptosis, angiogenesis, and immune cell functions. Notably, let-7d targets oncogenes such as RAS and MYC, thus playing a critical role as a tumor suppressor in multiple cancer types, though its specific function can be context-dependent. Dysregulation of let-7d contributes to carcinogenesis, resistance to therapy, and a range of gynecological and developmental diseases. It is being investigated as both a therapeutic target/agent (primarily via miRNA mimics) and as a biomarker for disease diagnosis, prognosis, and therapy response. Clinical application is promising but challenged by issues related to delivery and safety because miRNAs like let-7d have broad regulatory roles in both normal and disease states[1][2][3][5][7].

Other names

hsa-let-7dMIRLET7DLET7DMIRNLET7Dlet-7d

When used as a therapeutic mimic, let-7d acts by restoring/replacing tumor suppressive microRNA function to downregulate oncogenic target mRNAs (e.g., RAS, MYC, HMGA2, IGF1R). Indirect modulation of gene expression that results in inhibition of cell proliferation and promotion of differentiation and apoptosis.