Lethal-7d-3p microRNA (let-7d-3p)

Lethal-7d-3p microRNA (let-7d-3p) is a small, non-coding RNA molecule belonging to the highly conserved let-7 family, which is essential for regulating gene expression at the post-transcriptional level [1, 5]. It functions primarily by binding to the 3' untranslated regions (3' UTR) of target messenger RNAs, leading to their degradation or the inhibition of their translation into proteins [2, 12]. In many contexts, let-7d-3p acts as a tumor suppressor by targeting oncogenes such as KRAS, HMGA2, and C-MYC, and its downregulation is frequently observed in various cancers, including ovarian and cervical malignancies [1, 13]. Beyond oncology, let-7d-3p is involved in the pathophysiology of cardiovascular diseases like heart failure and inflammatory conditions such as sepsis, where it often serves as a circulating biomarker for diagnosis and prognosis [6, 7]. Therapeutic strategies targeting let-7d-3p include the use of miRNA mimics to restore its function in disease states or antisense oligonucleotides (antimiRs) to inhibit its activity when it is pathologically upregulated [2, 10]. However, the clinical application of these therapies faces challenges related to precise delivery and the potential for off-target effects due to the miRNA's ability to regulate multiple gene targets simultaneously [14, 15]. Its role in neurogenesis and mood disorders also suggests potential applications in psychiatric therapy [9].

Other names

hsa-let-7d-3plet-7d-3plet-7d*MIMAT0004484MicroRNA let-7d-3p

Binds to the 3' untranslated region (3' UTR) of target mRNAs to induce translational repression or mRNA cleavage