Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Leucine rich adaptor protein 1 (LURAP1)
- Target
- LURAP1
- Molecular classification
- Other (adaptor protein, cytoplasmic signaling scaffold)
01
Overview
Leucine rich adaptor protein 1 (LURAP1) is a cytoplasmic adaptor or scaffold protein characterized by two N-terminal leucine-rich repeats and a C-terminal PDZ-binding motif[1][8]. It regulates actin cytoskeleton dynamics and cell migration by forming a complex with CDC42BPA/CDC42BPB and MYO18A, promoting actomyosin assembly and cell protrusion[3][5]. LURAP1 plays a crucial role in vertebrate embryo development, notably in convergence and extension (CE) movements during gastrulation, acting through modulation of Wnt/planar cell polarity (PCP) signaling and interacting with Dishevelled and JNK to coordinate cell polarity[1]. LURAP1 also serves as an activator of the canonical NF-kappa-B pathway, enhancing pro-inflammatory cytokine production and supporting dendritic cell antigen-presenting functions[3][5]. There is no evidence LURAP1 is a direct drug target or clinically actionable biomarker at this time[3][5].
- Other names
- C1orf190LRAP35ALRP35AFLJ25163leucine repeat adaptor protein 35ANF-kappa-B activator C1orf190LRAP35a
02
Biological functions
Signal transduction (Wnt/PCP and NF-kappa-B pathways)Cell migration and motilityCytoskeleton organizationAntigen-presenting function in dendritic cells
03
Disease associations
Other (role in embryonic development, cell polarity, immune response; no well-established direct link to major diseases such as cancer or neurodegeneration in current sources)
Beyond the preview
Go deeper on Leucine rich adaptor protein 1 (LURAP1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Leucine rich adaptor protein 1 (LURAP1).