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Target intelligence / Profile preview
Leucine-rich repeat and calponin homology domain-containing protein 2 (LRCH2)
- Target
- LRCH2
- Molecular classification
- Cytoskeletal regulator, Scaffold protein, Other (not a receptor, channel, transporter, enzyme, or transcription factor)
01
Overview
Leucine-rich repeat and calponin homology domain-containing protein 2 (LRCH2) is a cytoskeletal regulator protein characterized by multiple N-terminal leucine-rich repeats (LRR) and a C-terminal calponin homology (CH) domain, conserved across animal species. The LRR domain mediates protein-protein interactions, while the CH domain structurally associates with actin filaments. LRCH2 acts as a scaffold protein implicated in cytoskeletal organization, cell division, and migration, particularly in leukocytes, suggesting roles in immune surveillance and actin cytoskeleton dynamics. A similar protein in Drosophila shows related cytoskeletal functions. LRCH2 is not currently recognized as a druggable therapeutic target, and alternative splicing produces several transcript variants. Diseases associated with LRCH2 include demyelinating polyneuropathy and spinocerebellar ataxia 44, though the pathophysiological mechanisms are not well understood.
- Other names
- LRCH2KIAA1495dA204F4.4leucine-rich repeat and calponin homology domain-containing protein 2LRCH family member 2
02
Mechanism of action
Not applicable; no drugs target LRCH2 directly.
03
Biological functions
Organization of the cytoskeletonProtein-protein interactions (via LRR domain)Actin filament interaction and regulation, potentially via CH domainCell division regulationCell migration, especially in leukocytesImmune response modulation (in leukocytes)
04
Disease associations
Demyelinating polyneuropathySpinocerebellar ataxia 44Possible involvement in immune-related and neurodegenerative conditions (suggested, not yet confirmed as disease causative)
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