Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Leucine-rich repeat and fibronectin type-III domain-containing protein 3 (LRFN3)
- Target
- LRFN3
- Molecular classification
- Cell adhesion molecule, Synaptic adhesion molecule, Other
01
Overview
Leucine-rich repeat and fibronectin type-III domain-containing protein 3 (LRFN3) is a cell surface adhesion molecule that mediates homophilic cell-cell adhesion in a calcium-independent fashion and promotes neurite outgrowth in neurons, particularly in the hippocampus. It has a predicted role in the regulation of presynaptic assembly and synaptic membrane adhesion and is located at the plasma membrane and presynaptic active zones. Mutations or dysregulation have been associated with neurodevelopmental and neuropsychiatric disorders such as autism spectrum disorder and familial adult myoclonic epilepsy 5.
- Other names
- SALM4FIGLER1Synaptic adhesion-like molecule 4Fibronectin type III, immunoglobulin and leucine rich repeat domains 1MGC2656
02
Biological functions
Regulation of presynapse assemblySynaptic membrane adhesionPromoting neurite outgrowth
03
Disease associations
Autism spectrum disorderFamilial adult myoclonic epilepsy 5Other (potential link to neurological disorders)
Beyond the preview
Go deeper on Leucine-rich repeat and fibronectin type-III domain-containing protein 3 (LRFN3).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Leucine-rich repeat and fibronectin type-III domain-containing protein 3 (LRFN3).