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Leucine-rich repeat and guanylate kinase domain-containing protein (LRGUK)
- Target
- LRGUK
- Molecular classification
- Other, Leucine-rich repeat protein, Guanylate kinase domain-containing protein
01
Overview
Leucine-rich repeat and guanylate kinase domain-containing protein (LRGUK) is a cytosolic protein characterized by the presence of leucine-rich repeats and a guanylate kinase-like domain[1][2][4][3]. It is highly expressed in testis, especially in germ cells undergoing spermatogenesis, where it is essential for proper sperm assembly, encompassing roles in acrosome attachment, manchette function, sperm head shaping, and axoneme development[2][4][3]. Mutations in LRGUK disrupt these processes, leading to abnormal sperm morphology and male infertility, as shown in animal models[2]. While predicted to possess GMP kinase activity, it is not classified as an enzyme, receptor, transporter, or canonical therapeutic target family[3][4]. No currently known drugs target LRGUK, nor is it validated as a clinical biomarker or implicated in therapy; its main significance is as an essential structural and assembly protein for male germ cell function and fertility[2][3][4].
- Other names
- LRGUKFLJ32786CFAP246Leucine rich repeats and guanylate kinase domain containing
02
Biological functions
SpermatogenesisAxoneme assemblySperm head shapingAcrosome attachmentMicrotubule dynamics
03
Disease associations
Male infertilityPrimary ciliary dyskinesiaOther
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