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Leucine rich repeat and Ig domain containing 4 (LINGO4)
- Target
- LINGO4
- Molecular classification
- Immunoglobulin superfamily domain containing, Leucine-rich repeat family, Membrane-associated protein
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Overview
Leucine rich repeat and Ig domain containing 4 (LINGO4) is a membrane-associated protein found primarily in the central nervous system. It is part of the immunoglobulin superfamily and contains leucine-rich repeat regions. LINGO4 is predicted to contribute to synapse assembly, neural development, axonal myelination, neural repair, and synaptic plasticity, though its precise physiological and pathological roles remain incompletely characterized. LINGO4 has functional associations across a broad set of biological entities, but currently no specific therapeutics, drugs, or established biomarker roles are attributed to it. Disease associations in public databases include essential tremor and ichthyosis vulgaris, but these links require further research to clarify causality or mechanism.
- Other names
- LRRN6DDAAT9248PRO34002UNQ9248/PRO34002Leucine-rich repeat neuronal protein 6Dleucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 4LIGO4
02
Biological functions
Synapse assemblyNeural development and axonal myelinationNeural repairSynaptic plasticity
03
Disease associations
Essential tremorIchthyosis vulgarisOther (includes broad CNS relevance, potential but unconfirmed links to neurodegenerative or neurodevelopmental diseases)
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