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Leucine-rich repeat and immunoglobulin-like domain-containing Nogo receptor-interacting protein 1 (LINGO-1)
- Target
- LINGO-1
- Molecular classification
- Type I transmembrane protein
01
Overview
Leucine-rich repeat and immunoglobulin-like domain-containing Nogo receptor-interacting protein 1 (LINGO-1) is a single-pass type I transmembrane protein primarily expressed in the central nervous system (CNS). It plays a critical role as a negative regulator of myelination and axonal regeneration, acting through its involvement in the Nogo receptor signaling complex. LINGO-1 is an attractive therapeutic target for demyelinating diseases like multiple sclerosis and neurodegenerative disorders such as Parkinson's disease.
- Other names
- Leucin-rich repeat neuronal protein 6ALRRN6A
02
Mechanism of action
Pharmacological inhibition/blockade of LINGO-1
03
Biological functions
Negative regulation of myelinationInhibition of axon regenerationRegulation of EGFR/Akt signaling
04
Disease associations
Multiple sclerosisParkinson's diseaseNeurodegenerative diseaseCNS injury
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