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Target intelligence / Profile preview
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 (LINGO2)
- Target
- LINGO2
- Molecular classification
- Immunoglobulin superfamily protein, Leucine-rich repeat (LRR) family, Membrane protein, Other
01
Overview
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 (LINGO2) is a member of the LRR and immunoglobulin superfamily, encoded by the LINGO2 gene. It is a membrane protein predicted to function in the regulation of synapse assembly and is active in the nervous system, with critical roles in neuronal development and vulnerability. Genetic studies link LINGO2 to increased risk of neurodegenerative diseases such as essential tremor and Parkinson’s disease, while variants and expression changes have been associated with gastric cancer progression and metabolic conditions. Its diverse roles suggest functions bridging neurobiology, oncology, and metabolic regulation[1][3].
- Other names
- LERN3LRRN6CLeucine-rich repeat neuronal protein 3Leucine-rich repeat neuronal protein 6CLeucine rich repeat neuronal 6CUNQ9234/PRO31993
02
Biological functions
Synapse assembly (positive regulation)Modulation of neuronal function and vulnerabilityCell motility and stemness (especially in cancer contexts)Metabolic regulation
03
Disease associations
Neurodegenerative disease (e.g., Parkinson's disease, essential tremor, autism spectrum disorder)Cancer (especially gastric cancer)Metabolic disease (gestational diabetes, BMI traits)
04
Biomarkers
Disease risk SNPs (e.g., rs7033345, rs10812774 in movement disorders)
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