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Leucine-rich repeat and transmembrane domain-containing protein 1 (LRTM1)
- Target
- LRTM1
- Molecular classification
- Other, Leucine-rich repeat protein, single-pass type I transmembrane protein
01
Overview
Leucine-rich repeat and transmembrane domain-containing protein 1 (LRTM1) is a protein enriched in insulin-sensitive tissues and the brain, functioning as a sensor of insulin receptor signaling and postreceptor regulator of metabolic and behavioral activity. Whole-body knockout mice show improved insulin sensitivity, increased lean mass, and hyperactivity due to altered dopamine signaling, indicating a role in both metabolic homeostasis and neuromodulation but not classical receptor-mediated signaling or enzyme/transporter substance transfer[2][5]. LRTM1 is unrelated to the better-characterized LRR/GPCR families, and no direct ligands or drugs are known to interact with it currently.
- Other names
- HT017leucine rich repeat transmembrane protein 1leucine-rich repeat and transmembrane domain-containing protein 1leucine rich repeats and transmembrane domains 1
02
Mechanism of action
No known mechanisms of drug action as it is not an established drug target.
03
Biological functions
Regulation of metabolic response to insulinSensing insulin receptor signaling changesRegulation of behavioral activity (dopamine signaling)Postreceptor regulation in muscle and brain
04
Disease associations
Metabolic disorders (e.g., roles in glucose homeostasis and fat/lean mass regulation)Neuropsychiatric/behavioral alterations (hyperactivity via dopamine signaling disruptions)Other (as LRTM1 KO mice display altered metabolism and behavior, but no direct disease causation documented[2])
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