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Target intelligence / Profile preview
Leucine-rich repeat containing 15 (LRRC15)
- Target
- LRRC15
- Molecular classification
- Leucine-rich repeat protein, Transmembrane protein
01
Overview
Leucine-rich repeat containing 15 (LRRC15) is a cell membrane-expressed protein involved in cell–cell and cell–extracellular matrix (ECM) interactions. It belongs to the leucine-rich repeat (LRR) superfamily. It plays roles in fibronectin, laminin and collagen binding. Aberrant expression is observed across various solid tumors and modulates SARS-CoV-2 infectivity.
- Other names
- LRRC15LIB
02
Mechanism of action
Modulation of viral entry; modulation of ECM interactions; inhibition of protein kinase activity
03
Biological functions
Fibronectin bindingLaminin bindingCollagen bindingProtein sequesteringProtein kinase inhibitorNegative regulation of protein localization to plasma membraneNegative regulation of viral entry into host cellsReceptor-mediated virion attachment to host cellsCell-cell interactionsCell-ECM interactions
04
Disease associations
CancerInfectionCOVID-19
05
Safety considerations
Potential for off-target effects due to broad ECM interactionsModulation of immune responses
06
Biomarkers
Cancer progression/metastasisCOVID-19 severity
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