Leucine-rich repeat-containing 37B pseudogene (LRRC37BP)

Leucine-rich repeat-containing 37B pseudogene (often referred to as LRRC37BP1, LRRC37B2, or just LRRC37B pseudogene) is a **pseudogene** in the human genome. Pseudogenes are nonfunctional copies of genes that have accumulated disabling mutations, such as frameshifts or premature stop codons, rendering them incapable of producing functional proteins[2][5][6]. The LRRC37 family contains functional paralogs—such as LRRC37B—that are protein coding, but this pseudogene variant does not code for a functional protein and shows no evidence of direct biological activity or involvement in diseases. Pseudogenes may retain sequence similarity to their ancestral functional genes but are not considered therapeutic targets or active molecular participants in cellular pathways. Their main relevance is in genome annotation, evolutionary studies, or as potential sources of regulatory RNA, but there is currently *no evidence* implicating "leucine-rich repeat-containing 37B pseudogene" in therapeutic targeting, drug interactions, disease mechanisms, or as a biomarker[2][5][6]. **Additional context:** - Pseudogenes can sometimes interfere with molecular genetic assays (e.g., PCR amplification bias) but do not encode active proteins or serve as drug targets[2][5]. - Confusion occasionally occurs between pseudogenes and their functional gene paralogs (e.g., LRRC37B), which should not be conflated. The ENSG00000273609 entry, as specified, refers to a pseudogene, not the protein-coding LRRC37B[6]—**which is a separate entity altogether and is also not recognized as a therapeutic target.** - If a therapeutic or experimental context refers to LRRC37B as a target, the pseudogene entry should be corrected to point to the functional protein-coding gene rather than the pseudogene. **In summary:** ENSG00000273609 is a **pseudogene** with no known protein product, biological function, druggability, or disease role, so it is not considered a therapeutic target, and its entry as such is likely either incorrect or a misannotation[2][5][6].

Other names

LRRC37BP1LRRC37B pseudogene 1LRRC37B2

None applicable