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Target intelligence / Profile preview
Leucine-rich repeat containing G-protein-coupled receptor 5 (LGR5)
- Target
- LGR5
- Molecular classification
- G protein-coupled receptor, Receptor, GPCR family 1
01
Overview
LGR5 is a G protein-coupled receptor that functions as a stem cell marker in various tissues, particularly the intestinal epithelium and hair follicles. It potentiates Wnt signaling upon binding R-spondins and is frequently overexpressed in colorectal cancer, making it a target for cancer therapies.
- Other names
- GPR49GPR67
02
Mechanism of action
Monoclonal antibodies or CAR-T approaches targeting LGR5
03
Biological functions
Signal transductionStem cell maintenanceWnt signaling modulationCell proliferationTissue homeostasisCell-cell adhesion
04
Disease associations
CancerColorectal cancer
05
Safety considerations
Potential for off-target effects due to LGR5 expression in normal stem cellsRisk of immune-related adverse events with CAR-T cell therapy
06
Biomarkers
LGR5 expression in colorectal cancer cells as a marker for cancer stem cells
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