Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Leucine-rich repeat-containing G protein-coupled receptor 6 (LGR6)
- Target
- LGR6
- Molecular classification
- G protein-coupled receptor, Rhodopsin-like receptor, Receptor
01
Overview
Leucine-rich repeat-containing G protein-coupled receptor 6 (LGR6) is a member of the G protein-coupled receptor superfamily distinguished by 17 leucine-rich repeats flanked by cysteine-rich motifs in its large N-terminal extracellular domain. LGR6 serves as a high-affinity receptor for R-spondins 1–3, enhancing canonical Wnt/β-catenin signaling primarily through increased LRP6 phosphorylation. It is not coupled to canonical heterotrimeric G-protein signaling upon ligand binding. LGR6 identifies populations of multipotent stem cells in tissues such as skin and is involved in tissue regeneration and tumor suppression, with roles described in several cancers, and modulates cardiac hypertrophy via metabolic pathways[1][2][4][5][6][8].
- Other names
- LGR6leucine-rich repeat containing G protein-coupled receptor 6leucine rich repeat containing G protein-coupled receptor 6GPCRVTS20631
02
Mechanism of action
Potentiation/activation of Wnt/β-catenin signaling (via R-spondin binding); Modulation of signaling pathways (including USP4-PPARα)
03
Biological functions
Signal transductionWnt signaling pathway mediationStem cell marker (in epidermis and squamous cell carcinoma)Promotes osteogenesis
04
Disease associations
Cancer (including colon cancer, cervical cancer, squamous cell carcinoma)Cardiovascular disease (cardiac hypertrophy modulation)
05
Biomarkers
Marker of multipotent epidermal stem cellsMarker for certain cancer stem cells (e.g., cervical, skin)
Beyond the preview
Go deeper on Leucine-rich repeat-containing G protein-coupled receptor 6 (LGR6).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Leucine-rich repeat-containing G protein-coupled receptor 6 (LGR6).