Leucine-rich repeat-containing protein 10 (LRRC10)

Leucine-rich repeat-containing protein 10 (LRRC10) is a highly conserved, cardiomyocyte-specific member of the leucine-rich repeat protein superfamily, expressed almost exclusively in heart tissue from early embryonic development through adulthood. LRRC10 localizes strongly to the Z-disc and dyad regions of cardiomyocytes, where it interacts with core contractile proteins like α-actinin and actin to regulate the cytoskeletal architecture crucial for normal cardiac function and excitation-contraction coupling. It is essential for maintaining proper heart muscle contraction, cytoskeletal integrity, and signaling responsive to mechanical stress in the heart. Genetic knockout models lacking LRRC10 develop dilated cardiomyopathy, and human LRRC10 mutations are linked to pediatric and familial idiopathic DCM. LRRC10 is also required for successful cytokinesis in heart muscle cells during development and regeneration, indicating a role in cardiac cell proliferation. No direct pharmacological agents target LRRC10, but its dysfunction has clear implications in inherited and acquired cardiovascular diseases, particularly those involving contractility defects and cardiomyopathy.

Other names

Leucine rich repeat containing 10LRRC10Aheart-restricted leucine-rich repeat proteinHRLRRP

Not applicable; no drugs directly target LRRC10