Leucine-rich repeat-containing protein 14B (LRRC14B)

Leucine-rich repeat-containing protein 14B (LRRC14B) is a protein-coding gene product belonging to the large family of leucine-rich repeat proteins, characterized by tandem repeats rich in the amino acid leucine[1][5]. It is classified as a member of the PRAME family and is expressed in a broad range of human tissues, with particularly broad but low-level tissue distribution[3][6]. There is insufficient evidence that LRRC14B is a direct therapeutic target, receptor, enzyme, or component of major signaling pathways, and its specific molecular function and role in pathophysiology remain unknown[1][5]. Mouse orthologs exist, suggesting a conserved but not well-characterized biological role[4][7]. LRRC14B is *not* considered a canonical therapeutic target (such as a receptor, enzyme, or transporter), nor are any interacting drugs or mechanisms currently described in the literature or key biological databases[1][5]. Available data confirm its classification as a leucine-rich repeat protein with unknown function and limited disease association[1][5].

Other names

LRRC14Bleucine rich repeat containing 14BLeucine-rich repeat-containing protein 14BLrrc14b (mouse)