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Target intelligence / Profile preview
Leucine-rich repeat-containing protein 15
- Molecular classification
- Leucine-rich repeat protein, Cell surface receptor
01
Overview
Leucine-rich repeat-containing protein 15 (LRRC15) is a cell membrane-expressed protein involved in cell-cell and cell-extracellular matrix interactions. It contains 15 leucine-rich repeats (LRRs) in its extracellular region, a transmembrane domain, and a short intracellular tail. LRRC15 is expressed in tissues such as the placenta, skin, activated fibroblasts in wounds, and lymphoid tissues. It binds fibronectin, laminin, and collagen, suggesting a role in cell adhesion. LRRC15 also interacts with the SARS-CoV-2 spike protein, inhibiting viral entry and inducing antiviral transcriptional programs. Aberrant expression has been observed in cancer-associated fibroblasts and some mesenchymal tumors.
- Other names
- LRRC15LIB
02
Mechanism of action
Modulates cell adhesion and signaling through interaction with ECM components and viral proteins; influences antiviral transcriptional programs.
03
Biological functions
Cell adhesionExtracellular matrix interactionIntegrin signalingInnate immunityAntiviral response regulation
04
Disease associations
CancerInfectionFibrosis (related to COVID-19)
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