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Leucine-rich repeat-containing protein 17 (LRRC17)
- Target
- LRRC17
- Molecular classification
- Other (Leucine-rich repeat-containing protein; not classified as receptor, enzyme, transporter, transcription factor, ion channel, histone modification, or related canonical therapeutic target class)
01
Overview
Leucine-rich repeat-containing protein 17 (LRRC17) is a human protein encoded by the LRRC17 gene. This protein is part of the leucine-rich repeat (LRR) family, which are typically involved in mediating protein–protein interactions. LRRC17 is mainly implicated in the regulation of bone metabolism, acting as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow cells. Its biological roles are primarily related to bone homeostasis and bone marrow development. The gene has been associated with certain diseases, such as reflex sympathetic dystrophy and neuroblastoma, likely through its influence on bone cell differentiation and the extracellular matrix. To date, LRRC17 is not classified as a canonical therapeutic target (such as a receptor, enzyme, or transporter), and there are no drugs specifically developed to interact with it. Its function may have broader implications in bone-related diseases, but it is not currently established as a biomarker or drug target[1][2][3].
- Other names
- LRRC17P37NBleucine rich repeat containing 17
02
Biological functions
Negative regulation of osteoclast differentiationBone homeostasisBone marrow developmentPotential roles in extracellular matrix interactions and protein–protein interactions (inferred from structural class)
03
Disease associations
Reflex sympathetic dystrophyNeuroblastomaOther (Modulation of bone diseases via osteoclast differentiation)
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