Leucine-rich repeat-containing protein 27 (LRRC27)

Leucine-rich repeat-containing protein 27 (LRRC27) is a protein encoded by the *LRRC27* gene located on chromosome 10q26.3 in humans, with notable transcript and protein expression in the brain and testis[1][2][3]. The protein is about 530 amino acids, features 5 leucine-rich repeat regions, and is predicted to be involved in actin binding, cytoskeletal, and cardiac muscle cell functions[1][2][3][6]. While its biological function is not fully defined, LRRC27 is implicated in disease processes such as preeclampsia (through platelet expression), primary open-angle glaucoma (through an associated SNP), and as an epigenetic biomarker for metabolic interventions[1][2][3]. There is no current evidence that LRRC27 is a direct therapeutic target, nor are there drugs known to modulate its function specifically. Its classification falls under "Other" as a leucine-rich repeat protein without established receptor, transporter, enzyme, or signaling protein functions[1][2][3][6].

Other names

KIAA1674Testicular tissue protein Li 108leucine rich repeat containing 27LRRC27