Target intelligence / Profile preview

Leucine-rich repeat-containing protein 3 (LRRC3)

Target
LRRC3
Molecular classification
Leucine-rich repeat family, Leucine-rich repeat and transmembrane domain-containing protein, Single-pass transmembrane protein (predicted)
01

Overview

Leucine-rich repeat-containing protein 3 is a member of the broad family of proteins characterized by leucine-rich repeat motifs, which are involved in protein-protein interactions. The LRRC3 protein is predicted to function at the plasma membrane, possibly as a signaling molecule or scaffold; it is predominantly expressed in the nervous system, suggesting a role in neural development or cellular connectivity. Its specific biological functions remain unclear, and there is no evidence for involvement in established signaling pathways, disease processes, nor any drug interactions with LRRC3 at present. The gene is annotated as protein coding with several known aliases, and it shares partial homology with other leucine-rich repeat-containing proteins that typically participate in immunity, development, or cellular signaling. Despite its membrane localization and nervous system expression, LRRC3 has not yet been classified as a therapeutic target or shown to have a direct pathogenic or pharmacological role.

Other names
LRRC3C21orf102LRRC3AUNQ9233/PRO31982LRRC3DNC21orf30DKFZP434C128AL117578
02

Biological functions

Localization and signaling at the plasma membrane (predicted)Nervous system development (predicted from expression, but not experimentally confirmed)
03

Disease associations

Possible association with indolent plasma cell myeloma (reported by GeneCards, not clinically validated)

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