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Target intelligence / Profile preview
Leucine-rich repeat-containing protein 37A2 (LRRC37A2)
- Target
- LRRC37A2
- Molecular classification
- Other (single-pass transmembrane protein, leucine-rich repeat family)
01
Overview
Leucine-rich repeat-containing protein 37A2 (LRRC37A2) is a predicted single-span transmembrane protein located in the membrane, whose gene resides in the complex chromosome 17q21.31 region[1][2]. The protein structure features multiple extracellular leucine-rich repeat (LRR) motifs, believed to be involved in protein–protein interactions or structural scaffolding. While the precise biological function remains unresolved, variation and abnormal expression of LRRC37A2 are associated with susceptibility to Parkinson's disease through effects on transcript levels in various brain tissues. LRRC37A2 is also implicated in gene fusion events in lymphomas, suggesting a broader relevance in neurodegenerative and oncogenic contexts. There are currently no known direct drug interactions, biomarker uses remain investigational, and its role as a classical therapeutic target (receptor, enzyme, transporter) is not established[1][3][5].
- Other names
- FLJ45049c114 SLIT-like testicular proteinLRRC37leucine-rich repeat-containing protein 37A2
02
Biological functions
Potential signaling or structural role via extracellular leucine-rich repeats (precise function not fully described)Implicated in transcriptional regulation in neurons and may affect dendritic growth and branching via fusion gene contexts
03
Disease associations
Neurodegenerative disease (Parkinson’s disease: transcript levels and genetic variation associated with disease risk)Cancer (identified in conjoined gene fusion events in non-Hodgkin B-cell lymphoma, T-cell lymphoblastic lymphoma)
04
Biomarkers
Potential biomarker for Parkinson's disease susceptibility based on differential expression and association with MAPT region risk variants
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