Leucine-rich repeat-containing protein 3C (LRRC3C)

Leucine-rich repeat-containing protein 3C (LRRC3C) is a **protein-coding gene** that encodes a predicted single-pass membrane protein with one transmembrane region and is part of the leucine-rich repeat protein family[3][11]. LRRC3C is located on chromosome 17q21 and is expressed predominantly in the **extracellular matrix and extracellular space**[2][11]. Genetic studies have linked LRRC3C to **immune-mediated diseases** (such as inflammatory bowel disease [IBD]) and **oncological disorders**. Risk alleles increase LRRC3C expression in the colon and are associated with increased disease susceptibility, possibly by affecting apoptosis and cell proliferation pathways[2][8][10]. Within the 17q12–21 locus (implicated in asthma and allergy), LRRC3C's functional contribution remains less defined compared to other neighboring genes[2][3]. In estrogen receptor–positive breast cancer, regulatory mutations at the LRRC3C locus alter gene expression and affect cell proliferation and therapy resistance[2]. While initially predicted to have signaling receptor activity, direct evidence for LRRC3C functional protein interactions or its therapeutic targeting is currently lacking[10][9]. Key points: - **Not a validated therapeutic target**; no drugs are known to interact with LRRC3C, nor is it regarded as a classic receptor, enzyme, or transporter. - **Aliases** include several gene/protein identifiers, with LRRC3C as the canonical abbreviation[1][11]. - **Genetic variants serve as biomarkers** for disease association studies[2][8][3]. - The **biological function and disease relevance** derive from genetic and expression studies rather than direct pharmacological or biochemical characterization[2][10].

Other names

leucine rich repeat containing 3CLRRC3Cputative LRRC3-like protein ENSP00000367157