Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Leucine-rich repeat-containing protein 46 (LRRC46)
- Target
- LRRC46
- Molecular classification
- Other (Leucine-rich repeat family protein), Structural protein/axonemal protein (testis-enriched, implicated in flagellum formation)
01
Overview
Leucine-rich repeat-containing protein 46 (LRRC46) is a member of the leucine-rich repeat (LRR) superfamily, typically localized at the midpiece of sperm flagella and highly expressed in adult testis. LRRC46 is essential for sperm flagellum formation and male fertility, as demonstrated by knockout mouse studies that show absent or malformed sperm flagella, reduced sperm count, impaired motility, and infertility. Mutations in LRRC46 lead to multiple morphological abnormalities of the sperm flagella (MMAF), making it a key factor in spermatogenesis but not currently a direct therapeutic target. Studies also suggest LRRC46 may be similar in function to other LRR proteins involved in axonemal assembly and ciliary function, with genetic disruption causing structural and functional deficits in sperm[2].
- Other names
- LRRC46MGC16309leucine-rich repeat-containing protein 46
02
Biological functions
Sperm flagellum biogenesisSpermatogenesisStructural integrity of sperm
03
Disease associations
Male infertility (multiple morphological abnormalities of the sperm flagella, MMAF)Other (flagellar/ciliary disorders, based on family relationships)
04
Biomarkers
LRRC46 mutations as diagnostic biomarker for MMAF-type male infertility
Beyond the preview
Go deeper on Leucine-rich repeat-containing protein 46 (LRRC46).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Leucine-rich repeat-containing protein 46 (LRRC46).